Abbas-qoli Khan (Persian: عباس‌قلی خان) was a 17th-century Safavid official in the eastern Caucasus.

Abbās-qoli Khan, known for his wealth and opulence, had served as beglarbeg of Ganja under the shah Suleiman I of Persia before being appointed as khan of Kakheti in eastern Georgia in 1688.

Abbas-qoli Khan's fortunes reversed as George was able to stage comeback and place Heraclius under siege at Tiflis in 1691.

In 1694, following the death of Shah Suleiman, the khan was accused by his rivals of incompetence and intriguing with George XI against Heraclius I.

At the order of Shah Sultan Husayn, Heraclius arrested Abbas-qoli Khan, confiscated his possessions, and escorted him under guard to Isfahan.