The Royal Hibernian Academy building used to be located in Abbey Street Lower but was destroyed in 1916.

In 1900, Maud Gonne founded Inghinidhe na hÉireann (The Daughters of Erin) at 32 Abbey Street Lower.

The former headquarters of Independent News & Media and its Irish Independent newspaper, 'Independent House,' is located on Abbey Street Middle, although the offices have since moved to nearby Talbot Street.

Independent House had previously been the offices of The Nation, a nationalist newspaper.

In 1785, James Napper Tandy stayed at 180 Abbey Street before eventually fleeing to the United States.