The monastery has supported a hospital for the sick, an agricultural colony, and an orphanage run by the Stigmata Sisters.

[2] The building was divided into a nave with two aisles with arches supported by columns, and raised presbytery over the crypt.

The present building was built over the earlier foundation by Cistercian monks and consecrated by Pope Innocent IV in 1253; the façade was completed in 1268.

[3] The urn of Saint Vittorino, a third-century bishop of Assisi and patron of the diocese, was made in 1954 for house his relics and those of other martyrs; it is in the high altar.

The museum displays a collection of art, including ceramic works by contemporary artists relating to Saint Francis and the Nativity.