He is the current Member of Parliament for Wa Central constituency in the Upper West Region of Ghana.

[clarification needed][3] Pelpuo entered the Parliament of Ghana in 2005 after winning the Wa Central seat on the ticket of the National Democratic Congress in the December 2004 election.

[6] He was replaced by Ghana's first female Minister for Sports, Akua Dansua, and appointed deputy Majority Leader in Parliament instead.

He was also nominated as one of Ghana's five Members to the Pan African Parliament in South Africa, where he served for a term until 2013.

In Parliament, Pelpuo became elected chairman of the Population and Development Caucus and Leader of the Parliamentarians for Global Action, Ghana Chapter.

He was appointed to serve another term as Chairman of the Population and Development Caucus and Ranking Member of the Lands Committee.

[8][9][10] In all, the National Democratic Congress won a minority total of 94 parliamentary representation out of 230 seats in the 4th parliament of the 4th republic of Ghana.