Two elders Opanin Addo Bruce and Yaw Tawiah (both deceased) gave out their buildings to house the college.
A new site was acquired for the college through Nana Adontenhene of Kwahu and indigenes of the Abetifi township.
Herbert Anim Oppong (former Clerk of General Assembly of the Presbyterian Church of Ghana).
At the beginning of the 1987/88 academic year as part of the 1987 New Educational Reforms, the college admitted students to start the Teacher's certificate ‘A’ 3-year post-secondary training programme, with the first batch graduating in 1991.
The programme was started during the 2004/2005 academic year and the first batch of 225 students who completed their course in July 2007.
In 2016, Abetifi College of Education signed an affiliation MoU with the University of Cape Coast.