[1] Schedel was initially employed as proof-reader in the printing establishment of Mordekhai Cohen.
In 1602, he and his brothers Judah Löb and Azriel founded the Schledel family press in the home of Hayyim ben Jacob ha-Kohen.
[2][3] Their first publication was a Yiddish paraphrase of the Bible entitled Maʾase yetziat Mitzrayim (1602–1906).
[4] They also published Ḥelkat meḥokek ('Portion of the Lawgiver'; 1606–1607), a commentary on the Passover Haggadah by their father, the preacher and dayyan Rabbi Moses ben Abraham (1585–1605).
He translated the Book of Ezekiel into Yiddish rime, and printed it in his own establishment in 1602.