Vuksanović began his career in the early nineties by performing alongside Serbian rock musician Viktorija and her band.

It was followed by Pesma od bola (Song Out Of Pain, 1996) and Lična karta (ID, 1998), on which he started working with prominent songwriters Marina Tucaković and Aleksandar Radulović Futa.

During the following years, he collaborated with Ivana Selakov on the singles "Daleko si" (2012), "Omaklo mi se" and "Ljubav u doba kokaina" (2015).

[4] In June 2013, Lukas held his biggest solo concert to date at the Marakana Stadium in Belgrade in front of 50,000 people.

[9] In March 2021, Vuksanović released his tenth studio album Uspavanka za ozbiljne bebe (Lullaby for Serious Babies) under City Records, which among other songs included duets "Kidaš me" and "Problem" with Milica Pavlović and Maya Berović, respectively.

[26][27] Following the assassination of Zoran Đinđić in 2003, Vuksanović was arrested for illegal gun possession during the police action Sablja and sentenced to four months of prison.

filed a complaint against Vuksanović in August 2020 for hate speech against LGBT community during his television appearance on Happy TV in January 2018.

[28] In November 2020, Vukasnović made misogynistic remarks against N1 journalist Žaklina Tatalović while appearing on a live talk show broadcast by TV Pink.

[30] In September 2022, it was reported that Vuksanović was criminally convicted for insults against Tatalović and ordered to pay her 250.000 RSD as well as to cover her court expenses.

[31] After the final of the Serbian selection competition for the Eurovision Song Contest 2022, Pesma za Evroviziju '22, where Lukas had placed 5th in the final with the song "Oskar", he accused Serbian public broadcaster RTS of irregularities in the voting of the selection, stating he would file a criminal complaint against the head of the Radio Television of Serbia, its editor of entertainment program Olivera Kovačević and general director Dragan Bujošević for "stealing votes".