Considered a separate species based on morphological distinction and isolated location, it shares a large portion of its genetics with Acanthodactylus pardalis in this genus.

The species is endemic to the loess scrublands of the Negev desert in Israel and the Palestinian Territories, a biodiversity hotspot.

Conservation efforts also damaged the population, but a small portion of their original range remains untouched and protected.

The Be'er Sheva fringe-fingered lizard lives in a structurally simple environment with few perches in which the species can hide from its predators.

The Be'er Sheva fringe-fingered lizard does not rely much on the perches or covers provided by trees for survival but is known to show the strongest reaction to plantations.

Because the species face a lot of threat from the many predators inhabiting the area, the Be'er Sheva fringe-fingered lizard has found ways to adapt its diet dependent to its predatory situation.

When under more than normal pressure from predators, the Be'er Sheva fringe-fingered lizard moves around less and catches and consumes smaller prey and less plant material.

The conservation plan constructed pits and planted trees in order to reduce resource leakage in the ecosystem.

The Be'er Sheva fringe-fingered lizard disappeared from its natural and altered habitats 11 years after the construction of the conservation plan.

It is also easily caught by birds, like falcons and egrets, whose numbers are increasing due to continued tree planting in its niche.