Acanthosis nigricans-muscle cramps-acral enlargement syndrome, also known as Acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome is an extremely rare genetic disorder which is characterized by the appearance of acanthosis nigricans, insulin resistance, muscle cramps of severe intensity, and acral hypertrophy/enlargement.

It was first discovered when Jeffrey Flier and his colleagues described two siblings of the opposite sex with the symptoms mentioned above.

(plus: large, chunky hands), the sister had virilized polycystic ovaries.

[5][6] The inheritance pattern of this disorder is thought to be autosomal recessive.

[7] This genetic disorder article is a stub.