Acatlan y Piastla was an alcaldia mayore in New Spain located in what is today Puebla State.
Prior to the coming of the Spanish this area was divided between the Mixtec kingdoms of Yucuyuxi, Chilla, Icxitlan and Petlaltzinco and the Nahuatl-speaking kingdom of Piastla.
All of these were tributary states of the Aztec Empire.
Spanish control was established in this region in 1521.
It was changed to an alcaldia mayore in 1558.