Acebutolol,[1] sold under the brand names Sectral among others, is a beta blocker for the treatment of hypertension and arrhythmias.

When possible, the treatment should be discontinued gradually in order to avoid a withdrawal syndrome with increased frequency of angina and even precipitation of myocardial infarction.

Acebutolol is a cardioselective beta-1 blocker which also considered a partial agonist due to its intrinsic sympathomimetic activity (ISA).

This means it provides low-grade beta stimulation at rest but acting as typical beta-blockers when sympathetic activity is high.

Acebutolol undergoes extensive hepatic metabolization resulting in the desbutyl amine acetolol which is readily converted into diacetolol.

Geriatric patients tend to have higher peak plasma levels of both acebutolol and diacetolol and a slightly prolonged excretion.