Acipimox (trade name Olbetam in Europe) is a niacin derivative used as a lipid-lowering agent.

[1] As with niacin and related drugs, the most common adverse effects are flushing (associated with prostaglandin D2[2]) and gastrointestinal disturbances such as indigestion, which occur in at least 10% of patients.

[citation needed] High doses can cause headache,[3] and precipitate gout.

[citation needed] In contrast to niacin, no impairment of glucose tolerance and no disorders of liver function have been found in studies, even under high doses of acipimox.

This reduces the concentration of fatty acids in the blood plasma and their inflow into the liver.