It has showcased early Ware comics, such as Quimby the Mouse from The Daily Texan, and more recent strips from NewCity, a Chicago weekly paper.

Jimmy Corrigan is the saga of a lonely childlike man and his alienated ancestors, partly inspired by Ware's hopeful but unhappy reunion with his absentee father.

In short, it just feels a little more like "art" to me now, since I’m responsible for everything that goes into it, and there’s no one to blame but myself if it's awful...[6] Issues are imbued with the defining characteristics of Ware's work; a pervasive sadness and nihilism permeate tales of disappointment, thwarted affection, and the dehumanization of the individual in a modern and mechanized world.

These interventions offer complex and simultaneous multilinear readings of the page that serve to thematise Ware's engagement with issues of narrative and continuity.

Ware won the Harvey Award for his work in Acme Novelty Library for Best Cartoonist of 2006; Best Letterer of 1996, 2000, 2002, and 2006; Best Cover Artist of 2000; and Best Colorist of 1996, 1997, 1998, 2000 and 2002.