[2]: 502 "Acral" refers to the fact that the peeling of the skin is most noticeable on the hands and feet of this state.

Peeling skin syndrome 1 is caused by a genetic defect in the corneodesmosin (CDSN) gene.

[10][11] Peeling skin syndrome 3 is caused by a genetic defect in the carbohydrate sulfotransferase (CHST8) gene.

Its symptoms begin during the second half of the primary decade of existence[clarification needed] and encompass generalized white scaling taking place over the upper and lower extremities.

[12] Peeling skin syndrome 4 is caused by a genetic defect in the cystatin A (CSTA) gene, an intracellular thiol proteinase inhibitor that has an essential role in desmosome-mediated intercellular adhesion inside the lower levels of the dermis.

Ointments are also used to minimize skin peeling and when the blister grows, sterile needles may be activated.

[19] Individuals should be informed to avoid exacerbating triggers such as trauma, humidity, heat, perspiration, and water.