The ACT-I-VATE collective featured serialized graphic novels from over twenty-five hand-picked professional cartoonists (each of whom generally added a new episode weekly), and was updated daily.

ACT-I-VATE members included Haspiel, Nick Bertozzi, Michel Fiffe, Dan Goldman, Tim Hamilton, Josh Neufeld, Leland Purvis, Mike Cavallaro, Kevin Colden, Molly Crabapple, Darryl Cunningham, Mike Dawson, Ulises Fariñas, Simon Fraser, Tom Hart, Roger Langridge, Jason Little, Paul Maybury, Warren Pleece, Palle Schmidt, Paul Peart-Smith, Dean Trippe, and Chip Zdarsky.

ACT-I-VATE rose to prominence when many of its artists, including Haspiel, Michel Fiffe, Mike Cavallaro, Dan Goldman, and Nick Bertozzi, began to receive publishing deals.

[6] Act-i-vate members Ulises Fariñas, Michel Fiffe, Dean Haspiel, Tim Hamilton, Dan Goldman, Paul Maybury, and Nikki Cook all had work published in Image Comics' Popgun anthology vol.

The book's 16 original comics were by Roger Langridge, Mike Dawson, Nick Bertozzi, Tim Hamilton, Dean Haspiel, Pedro Camargo, Mike Cavallaro, Molly Crabapple, Jim Dougan, Ulises Fariñas, Michel Fiffe, Maurice Fontenot, Simon Fraser, Jennifer Hayden, Joe Infurnari, John Leavitt, Hyeondo Park, and Leland Purvis.