The car was developed in collaboration between the company's divisions in Japan and the United States, and all models were hand-built at a dedicated factory in Ohio.

In July 2005, Honda's North American luxury brand Acura announced that a successor to the first-generation NSX was in development, with the original being discontinued at the end of the year.

[9] Over two years later in December 2007, Honda America's CEO, Tetsuo Iwamura, confirmed to the automotive press that the new sports car would be powered by a V10 engine and make its debut to the market by 2010.

[11] Prototypes of the vehicle were seen testing on the Nürburgring in June 2008,[12] with Honda's CEO Takeo Fukui challenging the developers to make the car faster than the Nissan GT-R around the track.

In late 2010 and early 2011, reports from various automotive magazines began to emerge that Honda was again planning to make a new sports car to be a successor to the original NSX,[16][17] and that it could use electric motors in addition to a petrol engine.

[18] Honda CEO Takanobu Ito confirmed in September 2011 that the company had begun development of a new sports car,[19] and by the end of the year in December, Acura announced that they would unveil the next generation of the NSX in concept form at the 2012 North American International Auto Show.

[37] The team therefore commissioned Honda's R&D Center in Tochigi, Japan to develop a brand-new engine specifically for the NSX with significantly higher performance.

[39] The development team tested, benchmarked and examined various cars from rival manufacturers, including the Ferrari 458 Italia, Audi R8 V10, Porsche 911 Turbo, Nissan GT-R and McLaren 12C.

[41] During these sessions, the team was able to fine-tune the car and its systems, with some changes being able to be made on the spot, and others, such as software modifications, through conference calls to Japan.

[43][44][45] After the production version was launched, development of future variants of the NSX was moved fully to Japan and Satoshi Mizukami assumed the role of large project leader.

[48] At the same time, Honda announced the European debut for the NSX at the 85th Geneva Motor Show, alongside the FK2 Civic Type R.[49] The first production vehicle with VIN #001 was auctioned off by Barrett Jackson on January 29, 2016.

[61] It is housed inside Honda's former North American Logistics facility, in the midst of their existing research and development (R&D) and production engineering operations.

[71] It is a twin-turbocharged, 75-degree 3,493 cc (3.5 L; 213.2 cu in) DOHC V6 unit, the bore and stroke of 91mm x 89.5mm, with a maximum power output of 500 hp (507 PS; 373 kW) delivered at 6,500–7,500 rpm.

[7] The turbochargers, positioned on both sides of the engine, are a single-scroll design and use electronic wastegates, providing a peak boost pressure of 15.23 psi (1.05 bar).

[71] This AWD system, named Sport Hybrid SH-AWD, can produce a yaw effect in situations where typical mechanical ones cannot, such as when little or no throttle is applied, because the electric motors operate independently from the internal combustion engine.

[71] The motors can also provide torque fill during gear changes and lower engine speeds, resulting in more constant and linear acceleration.

The gearbox, designed and built in-house by Honda, is a longitudinal nine-speed dual-clutch transmission (DCT) that can be operated with paddle-shifters behind the steering wheel.

[82] In September 2021, Acura conducted a test for the NSX Type S around the Grand Prix of Long Beach street circuit with IMSA SportsCar champion Ricky Taylor driving.

These led to software optimizations to the Sport Hybrid SH-AWD system, active magnetorheological dampers, electric power steering and VSA settings.

[87][88] On August 3, 2021, Honda announced they would produce an improved, limited-production NSX Type S for 2022 to mark the car's final year of production.

Because of the improvements in battery capacity and output, the car's electric motors have been retuned to offer better performance and a higher electric-only range.

All 300 Type S models in the United States were reserved with deposits within 24 hours of the car's launch, with a waiting list that includes more than 100 people.

[111] The NSX also won the AutoGuide.com Readers' Choice Car of the Year Award for achieving high performance with a natural driving feel.

[117] Automobile staff voted the NSX to its list of 2017 All-Stars; the car won the honor "by consistently putting a grin on drivers' faces" during testing.

[126] Also, it is currently owned by Robert Downey Jr.[127] A Super Bowl advertisement for the vehicle began airing in early February 2012, featuring Jerry Seinfeld and Jay Leno.

[132][133] During the 2014 season, the NSX Concept-GT received its first pole and victory at Fuji Speedway in August, with the best-placed Honda driver fourth in the championship.

[136] Team Kunimitsu's NSX would win the GT500 title in an upset after the rival TOM'S Toyota GR Supra ran out of fuel at the end of the final lap of the championship race at Fuji Speedway.

[155] The 2022 GT World Challenge America season saw the Racers Edge Motorsports NSX GT3 Evo22 win the Pro-Am championship with drivers Mario Farnbacher and Ashton Harrison.

A production-based 2017 Acura NSX won the Time Attack 2 production-class at the 2016 Pikes Peak International Hill Climb on June 26th 2016.

[161] European sales statistics are from the following countries: Austria, Belgium, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland.