[6] In December 2008, the city was designated as a "Preserve America Community" by First Lady Laura Bush.

[8] Marysville was founded in 1819 by Samuel W. Cuthbertson, who named the town after his daughter Mary,[9] along the small waterway of Mill Creek.

The first county jail was a log structure that sat on the south side of East Center street, in the rear of the courthouse.

In 1852, the Agriculture Society moved the fair to the current location, on the north side of town.

The first permanent settlement was made by Abraham Amrine, of Swiss descent, in 1817, two miles north of the city.

[17] In 1828, Marysville's first school was established in the east side of town using a log cabin as its building structure.

In 1843, the first high school was opened by Caroline Humphrey, and by 1850 there was a Board of Education making annual reports to the voters.

[19] By 1846, Marysville had 360 inhabitants, three small dry goods stores, two churches (Presbyterian and Methodist), a private school, and a newspaper office.

[23] In 1877, the town council decided to build a city hall on the southeast corner of Main and South.

[25] By 1888, Marysville had earned itself the title of "the Shaded City" because of its tree-lined streets, and by 1890, its population increased to 2,832 residents.

[27] A wool company, Woodbury & Welsh, constructed a factory out of brick in the northeast part of town in 1864, and a brewery was built in 1866 on the east side.

[30] In 1840, Otway Curry, a poet of national fame and resident of Marysville, wrote the "Log Cabin Song".

It would inspire the Log Cabin Campaign of William Henry Harrison, who would go on to win the Presidential election that year.

The Congregational Church organized in 1864, with a building constructed on the northeast corner of West and South Street.

[citation needed] In 1948, Nestlé opened a research and development center in the West neighborhood.

A new city hall would be constructed on the southeast side of Uptown, which housed the police department.

Timberview, an upscale residential section on the south side, would be constructed, and included a golf course.

[citation needed] President George H. W. Bush visited in 1992 as part of his "whistle stop train tour" re-election campaign.

Marysville is the headquarters for Scotts Miracle-Gro Company, the largest producer in the world of horticulture products.

There is a regional Goodyear manufacturing facility, under the name of Veyance Technologies also located within city limits.

Nestlé, located on the west side of the city, has a Product Technology Center dedicated to ready-to-drink mixes.

[52] Scotts Miracle Gro also has their R&D operations located on their corporate campus east of the city.

The Transportation Research Center is located a few miles from Marysville in East Liberty near the Honda manufacturing campus.

The Piatt Castles, Covered Bridges of Union County, and the Big Darby Plains Scenic Byway are a short drive away.

It sports a 4,220-foot (1,290 m) runway for passenger and freight air service, and can accommodate private and/or executive aircraft.

[64] In 2009, Marysville became the first city in Central Ohio to employ the use of inflatable dam technology, which was built on Mill Creek.

[65] The city of Marysville is serviced by Dayton Power and Light, with the surrounding area also served, depending on location, by Union Rural Electric and AEP Ohio.

[34] In 2009, Memorial was named as one of the nation's most technologically improved centers by Health & Hospitals Network magazine.

In 2014, Memorial opened the City Gate Medical Center located at 120 Coleman's Crossing Blvd.

Moving to the area in 2011 was Central Ohio Clinic of Chiropractic and Dr. Brett J. Blitzstein, Chiropractor and founder and developer of JMR, Joint and Muscle Restoration technique.