The left-handed LaRoche platooned with 46-year-old veteran Julio Franco and put up a respectable .278 rookie batting average.

In addition, in a wild game against the San Diego Padres on July 14, 2006, LaRoche hit two more home runs and had five RBIs to help the Braves to a 15–12, 11-inning win.

During the 2009 season he played with his brother Andy LaRoche with the Pirates until July 22, 2009, when he was traded to the Boston Red Sox.

[4] LaRoche was traded to the Boston Red Sox[5] for minor league pitcher Hunter Strickland and shortstop Argenis Díaz.

On July 31, 2009, after only spending six games with Boston, he was dealt back to his former team, the Atlanta Braves, in exchange for first baseman Casey Kotchman.

[13] In early September, LaRoche homered in each game of a four-game series against the Chicago Cubs (and hit five home runs overall).

The only other players to match this feat are Hall-of-Fame sluggers Babe Ruth, Hank Greenberg, Yogi Berra, Johnny Bench, and Mike Schmidt.

[17] On January 8, 2013, LaRoche signed a two-year, $24 million contract to remain with the Nationals, that included a mutual option for 2015.

After the Nationals were eliminated in the NLDS by the San Francisco Giants, the team announced they would not pick up LaRoche's $15.3 million option, with the intent of moving Ryan Zimmerman to first base.

[19] LaRoche hit his 250th career home run off Detroit Tigers reliever Joakim Soria in a 4-3 White Sox win on June 6, 2015.

[22] The following day, teammates were close to boycotting their spring training game until manager Robin Ventura stepped in and told the players to play.

White Sox executive vice president Kenny Williams defended his request by stating "name one job in the country where you can bring your child to work every day.

"[28] He believes the answer is "to spread God’s word" and told The Washington Times, "I heard one chaplain put it this way: What do you want written on your tombstone?

"[28] Diagnosed with ADHD during his high school years, a blunder in the May 14, 2006, game against the Washington Nationals is attributed to that condition.

He picked up a Nick Johnson ground ball that should have resulted in the third out of the inning, but did not move quickly to step on first base.