He first earned recognition for starring as Max Blum in Happy Endings, as Dr. Peter Prentice in The Mindy Project, as Wade Whipple in Sonic the Hedgehog (2020), its sequels, and the spin-off series Knuckles (2024).

In 2012, it was reported that Pally and frequent collaborator Gil Ozeri wrote a script being produced by Will Ferrell & Adam McKay's company Gary Sanchez Productions.

[11] From April 2011 to May 2013, Pally starred as Max Blum, one of the lead characters on the ABC ensemble comedy series Happy Endings, alongside Eliza Coupe, Elisha Cuthbert, Zachary Knighton, Damon Wayans Jr., and Casey Wilson.

The cast reunited in July 2020 for the pandemic-themed episode "And the Pandemmy goes to..." to raise money for the charities Color of Change and World Central Kitchen.

[12][13] Following the cancellation of Happy Endings in 2013, Pally joined the cast of The Mindy Project as a series regular for the second and third seasons, playing the role of Dr. Peter Prentice.

[19][20][21] On June 5, 2015, Pally and fellow comedian friends Gil Ozeri and John Gemberling gained attention when they teamed with Funny or Die to live-stream their 50-hour marathon of Entourage, watching every episode in a row with no breaks for 50 hours straight.

He married his high school sweetheart Daniella Anne Pally (née Liben) on July 3, 2008;[1] the couple have three children: a son Cole (b.