[1] The film stars Natasha Lyonne and Judy Greer as two sisters who find themselves in trouble after housekeeper Shannon Jackson (Greer) accidentally kills a guest at the hotel employing her and younger sister Martha (Lyonne).

Realizing that Edwin cannot go back to his wife, Shannon takes her anger out by going to Boris' room to have sex with him.

Margaret invites Shannon in to convince her parents that Boris has moved on in life and has left Fresno to never come back or to talk to his family again.

They initially attempt to rob an adult store to steal all the merchandise and try to sell them to lesbians at an event being held at the local hotel they work at, only to discover they did not make enough money.

Two years later, it is revealed that she and Martha write letters to each other while Shannon is in prison, stating that "I hate you which in case you forgot means I love you like a sister."

The website's consensus reads: "While Greer and Lyonne's sisterly chemistry carries Addicted to Fresno, it's not enough to overlook the script's missteps in humor and levity.

[12] In a mixed review, CraveOnline wrote that it "is full of gleeful raunchiness and a registered sex offender or two, but not much actual comedy.

"[13] The Austin Chronicle wrote, "This heavy comedy, scripted by Karey Dornetto, delivers its expected yield of snappy and emotionally charged levity from a charismatic cast that also features Fred Armisen, Molly Shannon, and Aubrey Plaza in supporting roles.

Insufferable and unrepentant until far too late, we don't feel conflicted like we should when her lone true ally finally says 'enough is enough.'

"[14] Variety was also mixed in their opinion, as they felt that the work would likely not gather the cult following that Babbit's 1999 film But I'm a Cheerleader received and that Fresno was overall "a mean-spirited farce whose strenuous bad taste seldom translates into actual laughs.

"[15] Slant Magazine wrote, "Brightly lit and cheerfully acted, Jamie Babbit's Fresno pushes its not-so-funny premise almost to the breaking point, sacrificing character development on the altar of comedy along the way.

"[16] Aaron Hillis of The Village Voice called the film "consistently frickin' hilarious".

Judy Greer and Natasha Lyonne anchor it with a priceless good sister/bad sister dynamic; Lyonne is atypically sunny (and typically delightful) while Greer, as a bitter burnout, puts a sharp little spin on every line, turning each into a little dagger.

Aubrey Plaza also shines in a brief but juicy bit as a would-be love interest for Lyonne.