While in college, she aspired to become a journalist and reported for the Vassar Miscellany News, in addition to taking astronomy classes.
[7] Ames was a member of the American Astronomical Society and was elected to the International Committee on Nebulae and Clusters in 1928.
[8] Originally she had planned to become a journalist, but she found no work in the area and instead accepted a job as a research assistant at the Harvard College Observatory (HCO), a position she held until her death.
[10] In 1930, she published A catalog of 2778 nebulae including the Coma-Virgo group, which identified 214 NGC and 342 IC objects in the area of the Virgo cluster.
[11] During her tenure at the Harvard College Observatory, she worked together with Harlow Shapley on the Shapley-Ames catalog, which lists galaxies beyond the 13th magnitude.
[12] These results were significant because their finding of "general unevenness in distribution" of galaxies deviated from the assumption of isotropy.