Born in Boston, Massachusetts, she was a daughter of J. Foxcroft Cole, the landscape painter, and of Irma de Pelgrom, a Belgian pianist.
Chase traveled extensively with her parents in Europe and the American West as a young girl.
Chase studied at the School of the Museum of Fine Arts under Edmund C. Tarbell and Frank Weston Benson, in Paris under Jean-Paul Laurens and Carolus-Duran.
She was equally successful with portraits of children, young people, and those of older years, and with sitters of either sex.
"[2][3] She also won silver medals at the St. Louis World's Fair in 1904 and the Panama-Pacific International Exposition in San Francisco in 1915.