The former works to strengthen the State of Israel and the Jewish people,[2] while the latter focuses on healthcare.

[3] Noteworthy donations of the organization include: $50 million to the Dr. Miriam and Sheldon G. Adelson Educational Campus, another $67 million in total was donated to their Medical Research Foundation, and $33 million to the Birthright Israel Foundation, and $13 million toward paying for the promotional trips to Israel, Jerusalem and the Golan Heights that the nonprofit organizes for young Jewish people.

[4][5] In addition, the couple have pledged $3 million to Hebrew SeniorLife for housing facilities and a program to bring together older people and elementary-school students for education programs; $2 million to Gateways: Access to Jewish Education for programs for children with special needs; and $1 million to the Chelsea Jewish Foundation for specialized housing for patients with amyotrophic lateral sclerosis and multiple sclerosis.

Those pledges will be paid over five years,[4] and since 2007, the Adelson Family Foundation has made contributions totalling $140 million to Birthright Israel, which finances Jewish youth trips to Israel.

[7] The foundation funds the Maccabee Task Force, which combats antisemitism on college and university campuses in the United States.