After joining Italian club Atalanta in 2022, he won the UEFA Europa League in 2024, scoring a hat-trick in the final against Bayer Leverkusen and subsequently being named the African Footballer of the Year, becoming just the seventh Nigerian international to win the award.

[6] Lookman joined Charlton Athletic's academy in 2014 after signing from Waterloo, a youth football club based in the London Borough of Lambeth.

[11][12] He made his debut for the club ten days later in a 4–0 victory over Manchester City, replacing Ross Barkley in the 90th minute and scoring the team's fourth goal.

[13] Lookman made his first European appearance for Everton in a 1–0 win over MFK Ružomberok in the Europa League third qualifying round first leg.

However, the player insisted on an alternative move, and instead joined Bundesliga club RB Leipzig until the end of the 2017–18 season.

[22] On 4 August 2022, Lookman joined Serie A club Atalanta on a four-year contract for a reported fee of €15 million.

[26] On 22 May 2024, he scored his first career hat-trick, in the Europa League final at the Dublin Arena, as Atalanta defeated Bayer Leverkusen 3–0 to win the trophy for the first time in the club's history; in addition, he became the first player to score a hat-trick in a one-legged Men's European final since Pierino Prati in 1969.

[31] In early 2017, Lookman turned down the opportunity to switch allegiance to Nigeria after an approach from the national coach, Gernot Rohr.

[37] He subsequently rejected Nigeria's approaches for a third time in September 2018, after England senior manager Gareth Southgate convinced him that he was part of his plans.

[5] Lookman made his debut for Nigeria on 25 March 2022, in their scoreless draw with Ghana as part of the third round of the African section of qualification for the 2022 FIFA World Cup.