It has been associated with more aggressive characteristics when compared to adenocarcinoma in certain cancers.

[1][2] It is responsible for 1% to 4% of exocrine forms of pancreas cancer.

[4] On immunohistochemistry, it is typically positive for CK5/6, CK7 and p63, and negative for CK20, p16 and p53.

On genetic testing, KRAS and p53 are typically altered.

[4] This article incorporates public domain material from Dictionary of Cancer Terms.