At 13 Etomi left Nigeria for the United Kingdom, and had a diploma in physical and theatre art from the City College Coventry in 2004.

[19][20] Etomi began starring as Amaka Obiora, an undercover police officer, in Yemisi Wada's crime series LasGidi Cops, which debuted in June 2016 on television.

[26] In April 2021, Adesua and Banky W shared the story of their marriage and their struggles with conception and child bearing titled 'Final Say Faith'.

[29] In March 2025, Adesua Etomi brought widespread attention to Hyperemesis gravidarum by sharing her personal battle with the condition.

Her candidness and advocacy raised awareness about the challenges faced by women with severe pregnancy-related illnesses.