He was signed by the Miami Dolphins as an undrafted free agent in 2000 and also played for the Chicago Bears and Houston Texans.

Ogunleye played high school football at Tottenville High School in his hometown of Staten Island in New York City, He was a classmate of Major League Baseball All-Star starting pitcher Jason Marquis and a teammate of three-time Super Bowl-winning offensive guard Joe Andruzzi.

[7][8] During the 1999 season, he suffered a major knee injury, which ended his college career, and a staph infection, which caused him to lose 50 pounds.

By the end of his fourth season with the Miami Dolphins, Ogunleye had been voted starter in the 2004 NFL Pro Bowl.

During the 2005 NFL season, Ogunleye spearheaded the Bear's defensive line by recording ten sacks.

Ogunleye was named team captain and helped the Bears reach Super Bowl XLI in Miami during the 2006 season.

On September 14, 2010, Ogunleye signed a one-year tender with the Houston Texans after his contract with the Chicago Bears had expired.