[8] In humans, the gene for adipose differentiation related protein is located at short p arm of chromosome 9 at region 22 band 1 from base pair 19108391 to 19127606 (GRCh38.p7) (map).

1-115 amino acid sequences at N-terminal is highly similar with other perlipin family proteins and is required for stabilization of lipid droplets, 103-215 mid- region is needed for binding at lipid droplets while the C-terminal sequence from 220-437 forms four helix bundles.

Studies have shed light into potential molecular mechanisms in the fate determination of pre-adipocytes although the exact lineage of adipocyte is still unclear.

[13] In humans, a substitution mutation at the C-terminal region of perlipin 2 was shown to affect both the structure and function of the protein.

[11] At 251 position , serine residue was substituted by proline which results in the disruption of predicted alpha helical structure of the protein as well as reduction in the plasma triglycerides and lipolysis.

[16] Perlipin 2 protein around the macrophages and foam cells was found to play important role in formation of atheroma.

Downregulation of perlipin 2 inhibits the lipid droplet accumulation and decreases the likelihood to convert macrophages to foam cells.