[1] Natalini founded the architectural company Superstudio in 1966 along with Cristiano Toraldo di Francia, Gian Piero Frassinelli, Alessandro and Roberto Magris, and Alessandro Poli.
[2] At the end of the 1970s, Natalini became a member of the Architectural School of Pistoia with Roberto Barni, Umberto Buscioni, and Gianni Ruffi.
During this period, Natalini focused on projects in Italy and other parts of Europe.
Some of his projects include the Römerberg in Frankfurt, the Western Wall in Jerusalem, the Bank of Alzate Brianza, the Zola Predosa Power Center, and the Saalgasse House in Frankfurt.
[3] Natalini's works in Florence include the Teatro della Compagnia and the Museo dell'Opera del Duomo.