The Adoration of the Magi with Saint Helena is an oil painting on canvas of c. 1525–1526 by Palma Vecchio in the Pinacoteca di Brera, Milan.

[2] The canvas depicts the Gospel story of the adoration of the Christ Child by the Magi, with Saint Helena, who can be identified by her attribute the True Cross, anachronistically shown as being present at the scene.

[4] The positioning of Helena's cross above the figures of the Virgin and Child is a clear prefiguration of Christ's fate.

According to some critics the saint, prominently placed in the centre of the group of figures, is a representation of Lady Orsa who had commissioned the work.

[5] With the Napoleonic suppressions the canvas, like many other works, was removed from its original location and assigned to the Pinacoteca di Brera in Milan.