Adrenal fatigue or hypoadrenia is a pseudo-scientific term used by alternative medicine providers to suggest that the adrenal glands are exhausted and unable to produce adequate quantities of hormones, primarily cortisol, due to chronic stress or infections.
[3] The term "adrenal fatigue" was invented in 1998 by chiropractor James Wilson and applied to a collection of mostly non-specific symptoms.
[1][3] A systematic review found no evidence for the condition, supporting the consensus among mainstream endocrinologists that it is a myth.
[4] There is no evidence supporting the concept of adrenal fatigue, and it is not a valid diagnosis recognized by the scientific or medical communities.
[6] The concept of adrenal fatigue has given rise to an industry of dietary supplements marketed to treat the supposed condition.