He was born in Haarlem as the son of the engraver Jacob Matham and his wife Marijtgen or Maria van Poelenburgh.
[1] He was the brother of the engravers Jan and Theodor Matham, and became a member of the Haarlem St. Adriaen civic guard from 1624 to 1627.
In 1640, Matham was a member of a Dutch embassy to the king of Morocco, Mohammed esh Sheikh es Seghir, led by Antonius de Liedekerke.
[3] Adriaen Matham made a famous drawing and an engraving of the El Badi Palace, before it was destroyed.
[6] On his return journey to the Netherlands, he visited Madeira, with the crew of another ship on board, who had been kept in Morocco as slaves.