As a senior, he averaged 16.2 points, 8.3 rebounds, and 3.1 assists per game, and won All-Big East second team honors.

He spent the first three years of his career in the American minor leagues and in Italy (playing 8 games for Cordivari Roseto from July to October 1998).

[8] Griffin led the Pride to the CBA championship in the 1998–99 season as he was named the Finals Most Valuable Player.

Over six seasons, he played for the Boston Celtics, Dallas Mavericks, Houston Rockets and Chicago Bulls, averaging 4.4 points, 3.3 rebounds and one steal per game.

[10] Shortly after his playing career ended, he was hired by Milwaukee Bucks head coach Scott Skiles as an assistant, where he would work for the next two seasons.

This team featured many NBA stars including: Stephen Curry, James Harden, and Kyrie Irving.

On April 10, 2022, Griffin served as the acting head coach for the Raptors' final game of the 2021–22 regular season against the Knicks.

A few weeks prior to the game, Rivers said he would award his All Star ring and bonus check to Griffin.

His doctoral dissertation was titled "How Active NBA Assistant Coaches Experience Stress, Stressors, Coping Strategies, and Interventions in a Competitive Sports Environment.

[27][28] Griffin's son Adrian Jr. was a McDonald's All-American and five-star recruit in the class of 2021 and was drafted 16th overall to the Atlanta Hawks in 2022.