Adrian David Sampson (born October 7, 1991) is an American professional baseball pitcher who is a free agent.

He has previously played in Major League Baseball (MLB) for the Seattle Mariners, Texas Rangers and Chicago Cubs.

In July 2009, Sampson had Tommy John surgery, which caused him to miss his senior season.

[9] Sampson made his Major League debut on June 18, 2016 against the Boston Red Sox, relieving the injured Wade Miley.

[10][11] Scheduled to replace Miley in the rotation, Sampson suffered a torn flexor tendon while warming up before his first major league start five days later against the Detroit Tigers, which required season-ending surgery later that month.

[16][17] In 2017, Sampson rehabbed from the torn flexor tendon injury and made eight minor league appearances that season, going 2-2 with a 3.45 ERA in 31.1 innings with the AZL Rangers, Down East Wood Ducks, and the Round Rock Express.

Sampson spent the first 5 months of the 2018 season with the AAA Round Rock Express, going 8-4 with a 3.77 ERA in 126.2 innings.

[33] He made 21 appearances (19 starts) for Chicago in 2022, pitching to a 4-5 record and 3.11 ERA with 73 strikeouts in 104.1 innings of work.

On November 18, 2022, Sampson signed a one-year, $1.9 million contract with the Cubs, avoiding arbitration.

[34] In spring training in 2023, Sampson competed with Hayden Wesneski for the fifth starter role behind Marcus Stroman, Jameson Taillon, Drew Smyly, and Justin Steele.

He was optioned to Triple-A Iowa on March 25, after manager David Ross announced Wesneski had won the job.

[38] On August 1, 2023, the Cubs traded Sampson, Manuel Rodríguez, and international free agent bonus pool space to the Tampa Bay Rays in exchange for Josh Roberson.