[2] The New York Yankees selected Wesneski in the sixth round of the 2019 Major League Baseball draft.
[8] On August 1, 2022, the Yankees traded Wesneski to the Chicago Cubs for relief pitcher Scott Effross.
[12] He debuted that day and pitched five scoreless innings with eight strikeouts en route to his first career win.
In 2023, Wesneski made 34 appearances (11 starts) for the Cubs, and registered a 3–5 record and 4.63 ERA with 83 strikeouts across 89+1⁄3 innings pitched.
[17] On December 13, 2024, the Cubs traded Wesneski, Isaac Paredes, and Cam Smith to the Houston Astros in exchange for Kyle Tucker.