Adriana Cramer is a fictional character from the American daytime drama One Life to Live.

In May 2003, 15-year-old Adriana Colón arrives in Llanview to stay with her godmother, Carlotta Vega for the summer.

Disapproving of the relationship, Carlotta does everything she can to separate the lovers, culminating in having Adriana whisked to a convent school in Puerto Rico in September 2003.

While serving as the Ambassador to Mendorra in the mid-1980s, Dorian was introduced to mobster Manuel Santi, brother of her longtime maid, Carlotta Vega.

Upon giving birth to Adriana, fearing for the child's safety in light of Santi's reputation and lifestyle, Dorian placed her in the custody of the Colón family in Puerto Rico.

In the meantime, it is revealed that Antonio Vega is Santi's biological son and half-brother to Adriana.

In early 2005, Adriana begins dating Duke Buchanan, though their families are rivals and object to their involvement.

While there, the two are chased by Argentine thugs after overhearing a conversation between Asa and Carlo Hesser about eliminating one of the Cramer women and assuming that they were speaking of Adriana.

Adriana is bothered when Duke spends more time at his job at Buchanan Enterprises.

Adriana and Rex's new relationship is tested when she learns that he has aided and abetted a fugitive Todd Manning.

In the spring of 2006, Adriana begins modeling and quickly forges a successful career, resulting in her being stalked by an obsessed fan.

As Rex investigates who is behind the ordeal, Adriana mistakenly believes that he is the culprit and flees from him.

However, Adriana's attitude is seemingly based on jealousy towards Rex's ex-girlfriend, Gigi Morasco, rather than resentment towards Dorian.

Adriana blames Dorian for her problems with Rex while hating that she has become a manipulative schemer like her mother.

On September 18, 2008, Rex tells Adriana that he wants a divorce after realizing that she had known about Shane's paternity all along and had even provided Brody with the means to fake the DNA test.

In December 2009, it is mentioned that Adriana had been in a car accident; she survives, but Dorian attributes it to Mitch Laurence, who has been threatening to harm one of the Cramer women.