Previously, like its American version, it was a programming block aimed at adult audiences, broadcast by Cartoon Network (2005–2008); I.Sat in two different stages (first dubbed from 2007 to 2010 and then in the original language, subtitled in Spanish, from 2015 to 2020); TBS (2018–2020) and, finally, Warner Channel (2020–2021).

On December 1, 2010, I.Sat revealed that it was cutting Adult Swim programming due to low ratings, adding: "No matter if we add new shows, it would not work".

[8] Adult Swim relaunched in Latin America on April 3, 2015, on I.Sat, in English with Spanish subtitles, premiering Rick and Morty and many other shows for the first time on the region.

[10] After ceasing broadcasts on I.Sat and TBS, Warner Channel began airing the block on May 2, 2020, for Latin America and Brazil, with new content, such as Final Space and the rest of Aqua Teen Hunger Force and Robot Chicken series.

[14] On June 24, 2021, HBO Max announced a list of some original Adult Swim content that became available since the platform's launch, including: Rick and Morty, Aqua Teen Hunger Force, Robot Chicken, Primal, Squidbillies, The Shivering Truth, and Your Pretty Face is Going to Hell.

It airs classic Cartoon Network programming including Dexter's Laboratory, Cow and Chicken, Courage the Cowardly Dog, and Ed, Edd n Eddy.