[12] She was 7 years old when she moved from Kenya along with her mother to Adelaide, Australia as South Sudanese refugees seeking asylum.

After Melbourne Fashion Week, back home in Adelaide, she got a call from her agent confirming her for the Saint Laurent show, and took a flight to Paris a day after, making her major Fashion Week debut at Saint Laurent's S/S 17 show and signing to Elite Model Management in Paris.

[25][26] She is set to feature in the 2018 Pirelli Calendar, shot by Tim Walker, alongside Sasha Lane, Lil Yachty, Sean Combs, Whoopi Goldberg, RuPaul, Adwoa Aboah, Naomi Campbell and Slick Woods.

[31] In 2020, Adut Akech was featured beside Naomi Campbell in Beyonce's "Black Is King" for the song "Brown Skin Girl".

In 2022, Akech worked several fall fashion campaigns including Michael Kors and Victoria’s Secret.

Akech also appeared on the American Vogue for the May Issue alongside Natalia Vodianova, Devon Aoki, Naomi Campbell, Anok Yai, Gigi Hadid, Liu Wen, Amber Valletta, Shalom Harlow celebrating Karl Lagerfeld's legacy.

[38] Akech appeared on the cover of British Vogue for the March issue alongside Gigi Hadid, Kaia Gerber, Cindy Crawford, Iman, Kate Moss, Linda Evangelista, Cara Delevigne, Irina Shayk, Karlie Kloss, Vittoria Ceretti which celebrated 40 icons in the fashion industry.

[39] She was one of fifteen women selected to appear on the cover of the September 2019 issue of British Vogue, by guest editor Meghan, Duchess of Sussex.