Powers couldn't play for Michigan State in her first year due to a torn achilles tendon that she suffered in practice before the season started.

She was also named to the Big Ten All-Freshman Team and was a co-recipient for both Michigan State's Player of the Year and Spartan Hustle award.

In February 2016, Power earned espnW player of the week honors following her career-high 40 points (on 14–26 field goal shooting) along with 8 rebounds and 6 assists in a 114–106 win against Minnesota.

[7] Powers was selected to be a member of Team USA at the World University Games held in Seoul, South Korea from July 5–13, 2015.

Midway through the 2017 WNBA season on July 25, Powers made her return after recovering from hip surgery, scoring 9 points in 18 minutes off the bench in an 84–82 victory over the Indiana Fever.

[14] 2 games later, Power made her first and only start of the season for the Wings and scored a new career-high of 23 points in a 95–74 loss to the Los Angeles Sparks.

[15] The Wings finished as the number 7 seed in the league with a 16–18 record but lost to the Washington Mystics in the first-round elimination game, Powers scored 21 points off the bench in the loss.

In the semi-finals, the Mystics defeated the number 2 seed Atlanta Dream in a five-game series, advancing to the WNBA Finals for the first time in franchise history.

By the end of the season, Powers finished with a career-high in scoring, helping the Mystics a league-best 26–8 record, receiving a double-bye to the semi-finals.

[18] On August 7, 2020, Powers suffered a hamstring injury in a game against the New York Liberty and would be sidelined for the rest of the season, she was also averaging new career-highs in scoring, assists, steals and rebounds with her increased playing time.

[25] She underwent hip surgery and was ruled out for the off-season with an estimated recovery period of 4–6 months,[26] In 2017, Powers signed with Fenerbahçe S.K.

In January 2021, she was signed as a brand ambassador and streamer by Team Liquid, and appointed chair of its Diversity & Inclusion Task Force.