Part of the Administrative Zone 1, Afambo is bordered on the south by the Somali Region, on the west by Dubti, on the north by Asayita, and on the east by Djibouti.
As of 2008, Afambo has 79 kilometers of all-weather gravel road; around 22.33% of the total population has access to drinking water.
[2] Based on the 2007 Census conducted by the Central Statistical Agency of Ethiopia (CSA), this woreda has a total population of 24,153, of whom 13,312 are men and 10,841 women; with an area of 1,258.97 square kilometers, Afambo has a population density of 19.18.
[3] A sample enumeration performed by the CSA in 2001 interviewed 894 farmers in this woreda, who held an average of 4.61 hectares of land.
Of the 4.125 square kilometers of private land surveyed, 58.71% was under cultivation, 4.44% pasture, 33.92% fallow, and 6.42% was devoted to all other uses.