The Afram River is a 100-kilometre (62 mi) river in Ghana.

Prior to the construction of the Akosombo Dam in the 1960s, the Afram is a principal tributary of the Volta River and today is an equally important tributary of Lake Volta.

The river runs roughly in a southwesterly direction.

It collects all the drainage of the Kwahu Plateau.

This article related to a river in Ghana is a stub.