[1][2] The main campus is situated in the middle of the Masaai savannah, using the Ole Kasasi road, on 124 acres (50 ha), near the town of Ongata Rongai, adjacent to Nairobi National Park, approximately 22 kilometres (14 mi), by road, south of the city center of Nairobi, Kenya's capital and largest city.

The Church of the Nazarene sought to address African society's challenges in the early 1980s by implementing higher education.

Moreover, Africa Nazarene University looked into moulding the younger generation in an upright and Christian based environment.

[1] In July 1993, the board of the church granted its authority for the establishment of a university in Africa following a unanimous vote by its members during a General Assembly in Indianapolis, Indiana, USA.

[1] In August 1994 Dr. Martha John, the university's first Vice Chancellor, opened its doors to 62 students from eleven African countries taking undergraduate courses in Theology and Business Administration and a Masters of Arts in religion.