It is found in Angola, Botswana, Kenya, Malawi, Mozambique, Namibia, South Africa, Tanzania, Uganda, Zambia, Zimbabwe, and possibly the Democratic Republic of the Congo.

[1] It has long been confused with the edible bullfrog (P. edulis), and species boundaries between them, including exact range limits, are not fully understood.

[2] The natural habitat of the African bullfrog is moist to dry savanna, subtropical to tropical dry shrubland, intermittent freshwater lakes, intermittent freshwater marshes, arable land, pastureland, canals, and flooded ditches.

[12] An African bullfrog kept at the Pretoria Zoo in South Africa once ate 17 juvenile Rinkhals snakes (Hemachatus haemachatus).

[13] When exposed to dry conditions, they become dormant and may form a cocoon which covers the entire body surface except the external nostrils.

Eggs are laid in the shallow edge of the pond, but fertilization takes place above water.

The tadpoles hatch, and after two days, start feeding on vegetation, small fish, invertebrates, and even each other.

Due to the male bullfrog's overprotective behaviour, he pounces and bites anything that he views as a threat.

[19] However, conservation initiatives, such as habitat restoration, awareness campaigns, and legal protections, have been instrumental in reversing this trend, resulting in its reclassification to "least concern" in July 2013.