Compared to the lo-fi and ambient production of his previous instrumental releases, Afrikantis is less connected to musical concepts such as melody and harmony.

[3] Critics compared the album's sound to On the Corner (1972) by Miles Davis, Head Hunters (1973) by Herbie Hancock,[9] and the "orchestral vaporwave purveyed by James Ferraro and Orange Milk Records".

[3] A staff member from Sputnikmusic wrote that the song "Del the Funky Homosapien" sounded like it could be used as a backing track for its namesake, an American rapper.

[9] Steve "Flash" Juon of RapReviews wrote that the song "Guinea Pig Arcade" is a mix of bass guitar slaps, "a banjo picking jamboree", and "randomly chosen notes from the high end of a synthesizer".

[3][9] Juon described Afrikantis as "the audio version of the infinite monkey theorem", and felt it highlighted Lil B's weak production skills.

[7] Goldner called Afrikantis an "ocean of hopelessly annoying slop" and criticized its instrumentation, saying it was "seemingly recorded with the cheapest MIDI presets on the market".