In July 1969, he was a member of the delegation of the Russian Orthodox Church at the conference of representatives of all religions of the USSR for cooperation and peace between nations.

In 1990, the Vinnytsia regional branch of the Soviet Culture Fund nominated him as a candidate for People's Deputies of Ukraine in the Verkhovna Rada.

After the final split of the UOC MP and the election of Volodymyr (Sabodan) as Metropolitan of Kyiv, by the decision of the Synod of the Russian Orthodox Church dated 20 June 1992, Agafangel was appointed Metropolitan of Odesa and Izmail, the head of the Odesa Diocese of the UOC MP, part of whose faithful were dissatisfied with the pro-Ukrainian policy of the previous Archbishop Lazar.

He motivated his views by the fact that Ukraine's desire for Europe “is another attempt to implement the centuries-old desire of the Protestant-Catholic, Masonic and godless West to tear Ukraine away from unity with the world center of Orthodoxy - Moscow and drag it into the orbit of Western false values, to make it part of the new world system order.

"[13] Despite the fact that the church has no right to interfere in political affairs, Agafangel blessed the activities of the radical pro-Russian public organization "Edynoe Otechestvo" created by Valeriy Kaurov in 2001.

[19] Due to the fact that at these meetings, Archbishop of Pereyaslav-Khmelnytskyi Oleksandr (Drabinka), the secretary and "right hand" of Metropolitan Volodymyr, was dismissed from several of the most influential positions in the UOC, the mass media and independent observers accused a group of permanent members of the Synod as part of Metropolitans of Vyshgorod Pavlo (Lebedya ) and Hilarion of Donetsk (Shukal) led by Agafangel in an attempt to remove its superior from the practical management of the church, take power into his own hands and eliminate the independence of the UOC.

[20] Due to the illness of the superior, Agafangel also led the traditional thanksgiving prayer on Volodymyr Hill in 2011 with the participation of the country's highest officials.

[21] In October 2020, he banned Viktor Kochmar, a priest of the Odesa Diocese, from his ministry for participating in local elections as a candidate of the OTG.

During the stay of Metropolitan Agafangel at the Odesa Cathedral, 7 new monasteries were opened in the diocese: Panteleimonivskyi, Illinskyi, Iverskyi, Konstantino-Yelenivskyi and Mykolaivskyi for men, Michaelivskyi and Spaso-Preobrazhenskyi for women.

[22] The Odesa diocese, headed by Agafangel, is one of the few in the UOC (MP) that has not been divided for a long time since Ukraine gained independence.

Due to the efforts of Metropolitan Agafangel, the activity of the Bessarabian Metropolis of the Romanian Orthodox Church, which claims canonical jurisdiction over the region, was not extended to the Odesa Oblast.

In response, the man set the table with expensive imported drinks and invited to the holiday a dozen girls who provide intimate services, who were immigrants from the occupied Donbas.

These are radical statements against everything Ukrainian, this is even a denial of the term "Ukraine", and instead the use of such a favorite for chauvinists - "Little Russia" Protodeacon of the ROC Andriy Kuraev accuses Agafangel of unconventional orientation.

First of all, the union with Russia of Ukraine, Belarus, Central Asian and Caucasian peoples, which were previously part of the Russian Empire, is necessary.

[29] The Metropolitan is an opponent of globalization and ecumenism, believing that they need to be opposed with the help of the purity of faith and the preservation of traditions: the Julian calendar, fasting and the Church Slavonic language.

"[31] The reaction of the leadership of the Odesa diocese to the article in the Segodnya newspaper gained some publicity about the price list of church services.