[1][2] It is endemic to the central part of the Venezuelan Coastal Range.

[1][2][3] Agalychnis medinai inhabits cloud forests at elevations of 975–1,447 m (3,199–4,747 ft) above sea level.

It is a rarely spotted arboreal frog, usually seen in temporal or permanents pools, its breeding habitat, during the wet season.

It can also live in secondary forests near artificial bodies of water.

It is threatened by forest loss and extraction of surface water.