[1] During the late nineteenth and early twentieth centuries, it was cultivated for the table in the eastern United States.

[5] A. subrufescens forms fruit bodies singly or in clusters in leaf litter in rich soil, often in domestic habitats.

[6] Originally described from the northeastern U.S. and Canada, it has been found growing in California, Hawaii, Great Britain, the Netherlands, Taiwan, Philippines, Iran,[7] Australia, Brazil,[2] and Uruguay.

[9] The U.S. Food and Drug Administration has issued warning letters to companies marketing Agaricus supplement products with unproven health claims of providing benefits to the immune system.

[11][12] A. subrufescens is edible, with a somewhat sweet taste and an almond aroma resulting from benzaldehyde, benzyl alcohol, benzonitrile, and methyl benzoate.

[13] Used in traditional and alternative medicine for its supposed anti-cancer effects, Agaricus mushrooms have not been assessed by sufficient high-quality clinical research to define safety and biological properties upon consumption as a food, dietary supplement, or drug.