[3] Polybius states Agathoclea had relatives who served the Ptolemaic dynasty: Nikon a nauarch under Ptolemy IV;[4] and Philammon who was [5] appointed libyarch of Cyrene by her brother.
Despite Ptolemy IV marrying his sister Arsinoe III in 220 BC, Agathoclea continued to be his favourite.
[8] On the death of Ptolemy IV in 205, Agathoclea and her friends kept the event secret, that they might have an opportunity of plundering the royal treasury.
They also formed a conspiracy with Sosibius aimed at placing Agathocles on the throne or at least making him regent for the new king, Ptolemy V Epiphanes.
[9][10][11][12] There was another Agathoclea, the daughter of a man named Aristomenes, who was by birth an Acarnanian, and rose to great power in Egypt.