(Her husband's maternal grandfather, Agathocles of Syracuse, had ruled as the Greek Tyrant of Syracuse in Sicily from 317 to 289 BC and became king of much of Sicily[citation needed]; her husband's maternal grandmother, Theoxena of Syracuse, a Greek Macedonian noblewoman, was the second older maternal half-sister of the Greek-Egyptian Pharaoh Ptolemy II Philadelphus[citation needed], who reigned from 284 to 246 BC.)
[citation needed] Oenanthe's husband Agathocles died at an unknown date, and she later married Theogenes, sometimes known as Theognetos or Diognetos.
Through her children she exerted great influence over the Egyptian government in the reign of Ptolemy IV.
[3] In 205 BC, after the accession of the young Ptolemy V, the citizens of Alexandria rose up against Oenanthe, her family and their party,[4] who fled for refuge to the temple of the Thesmophorium.
The next day Oenanthe, her family and their party were dragged out from the altar by the Alexandrians and brought naked on horse-back to the stadium, where they were all murdered, being torn into pieces.