Agathoclea Theotropus (Ancient Greek: Ἀγαθόκλεια Θεότροπος, romanized: Agathokleia Theotropos; the epithet possibly means the Goddess-like) was an Indo-Greek queen married to Menander I, who ruled in parts of northern India in the 2nd-century BC as regent for her son Strato I.

Nonetheless, Agathoclea would become one of the first woman ruler in the Hellenistic world, and she seems to have been relatively significant due to her large presence on the coins of Strato I.

[2] In the civil wars after Menander's death, the Indo-Greek empire was divided, with Agathokleia and her young son Strato maintaining themselves in the eastern territories of Gandhara and Punjab.

The modern view, embraced by R. C. Senior and probably more solid since it is founded on numismatical analyses, suggests that Agathokleia was a later queen, perhaps ruling from 110 BC–100 BC or slightly later.

Some of her subjects may have been reluctant to accept an infant king with a queen regent: unlike the Seleucid and Ptolemaic Kingdoms, almost all Indo-Greek rulers were depicted as grown men.